분자생물학 G-CSF

분자생물학 G-CSF

[분자생물학] G-CSF.pptx

목차 01 Development background 02 Indication 03 Mechanism of drug action 04 Recombinant technology 05 Dosage form & Medication method 06 Product Type & Adverse reation 07 Reference 본문 Development background 2. History of development 1960s Discovery of colony-stimulating factors (CSF) 1980s GM-CSF, M-CSF, G-CSF and multi-CSF The human G-CSF was cloned Usage for the treatment at first 1990s first approval of Filgrastim by the US Food and Drug Administration Launched Lenograstim 2000s Launched PEG-filgrastim 참고문헌 1) Discovery of G-CSF and Early Clinical Studies Karl Welte G. Molineux et al. (eds.), Twenty Years of G-CSF, Milestones in Drug Therapy, 2) Mobilization of plasma cells in healthy individuals treated with granulocyte colony-stimulating factor for haematopoietic stem cell collection 3) Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells Masayuki Tsuchiya, Hitoshi Nomura, Shinetaka Asano, Yoshio Kaziro and Shigekazu Nagata 4) High level expression of a cDNA for human granulocyte colony stimulating factor in Chinese hamster ovary cells. 5) Characteristics of Hematopoitic Growth Factor, G-CSF and Its Clinical Vision Jeonghae Park1, Jung-Ae Park1, Seok-Woo Kang2, Tae-Won Goo2 and Kyung Tae Chung1* Homodimeric Crossover Structure of the Human GCSF-Receptor Signaling Complex, Proceeding of the National Academy of Sciences of the United States of America, 103, 2006, p.3135-3140 Granulocte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders Ivo P. Touw and Gert-Jan M. van de Geijn, Department of Hematology, Erasmus University Medical Center 키워드 분자생물학, 분자, 생물학